Research
Notes from the lab and field.
We track the peer-reviewed literature on every compound we supply and surface what matters for researchers.
1 Apr 2025
Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials
A systematic review and meta-analysis of randomised controlled trials found that retatrutide, a triple GLP-1/GIP/glucagon receptor agonist, produced significant improvements in body weight and metabolic outcomes in adults with obesity, with an acceptable safety profile.
1 Jan 2024
Tirzepatide as a novel effective and safe strategy for treating obesity: a systematic review and meta-analysis of randomized controlled trials
A systematic review and meta-analysis of 12 randomised controlled trials found that tirzepatide, a dual GIP/GLP-1 receptor agonist, significantly reduced body weight, BMI, and waist circumference, with gastrointestinal effects the main safety consideration.
1 Apr 2023
Semaglutide for the treatment of overweight and obesity: A review
A review of the STEP programme (Semaglutide Treatment Effect in People with obesity) covering trial designs, clinical outcomes, and the practicalities of using semaglutide 2.4 mg for weight management in adults with overweight and obesity.
1 Sept 2019
Bremelanotide (PT-141) for the Treatment of Hypoactive Sexual Desire Disorder
Two identical phase 3 trials evaluated subcutaneous bremelanotide (PT-141) in premenopausal women with hypoactive sexual desire disorder. Both showed significant improvements in sexual desire and related distress, with a favourable safety profile.
1 Jul 2014
Effect of Tesamorelin on Liver Fat and Visceral Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical Trial
A randomised clinical trial in patients with abdominal fat accumulation found that tesamorelin, a growth-hormone-releasing factor analogue, significantly reduced visceral and liver fat versus placebo, without worsening glucose control.